Michaelis-Menten speeds up tau-leaping under a wide range of conditions

TitleMichaelis-Menten speeds up tau-leaping under a wide range of conditions
Publication TypeJournal Article
Year of Publication2011
AuthorsWu, S., J. Fu, Y. Cao, and L. Petzold
JournalJOURNAL OF CHEMICAL PHYSICS
Volume134
Issue13
Date PublishedAPR 7
Type of ArticleArticle
ISSN0021-9606
Abstract

{This paper examines the benefits of Michaelis-Menten model reduction techniques in stochastic tau-leaping simulations. Results show that although the conditions for the validity of the reductions for tau-leaping remain the same as those for the stochastic simulation algorithm (SSA), the reductions result in a substantial speed-up for tau-leaping under a different range of conditions than they do for SSA. The reason of this discrepancy is that the time steps for SSA and for tau-leaping are determined by different properties of system dynamics. (C) 2011 American Institute of Physics. {[}doi: 10.1063/1.3576123]}

DOI10.1063/1.3576123