Structural Bioinformatics and Computational Molecular Biophysics

Contact: Alexey Onufriev

Our group uses computational methods to understand dynamics and function of large biomolecular systems such as proteins, DNA, and their complexes. Some of these methods are being developed in our lab. The computations are often performed on supercomputers such as VT's System-X.



We work at the interface of physics, biology, and computer science; the research is a collective effort of our group members who have background in one or more of these fields. The funding comes from the NIH and the NSF.

Active Research Areas:

  • Biomolecular Electrostatics
  • Protein Dynamics
  • DNA compaction and bending; Modeling of nucleosome dynamics
  • Insights into the RNAi mechanism