Structural Bioinformatics and Computational Molecular Biophysics
Contact: Alexey Onufriev Our group uses computational methods to understand dynamics and function of large biomolecular systems such as proteins, DNA, and their complexes. Some of these methods are being developed in our lab. The computations are often performed on supercomputers such as VT's System-X.
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We work at the interface of physics, biology, and computer science; the research is a collective effort of our group members who have background in one or more of these fields. The funding comes from the NIH and the NSF.
Active Research Areas:
- Biomolecular Electrostatics
- Protein Dynamics
- DNA compaction and bending; Modeling of nucleosome dynamics
- Insights into the RNAi mechanism
![]() | Alexey V OnufrievProfessor, Computer Science and Physics
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Computational Models for Gene Silencing: Elucidating A Pervasive Biological Defense
Granting Institution: National Science Foundation
Amount: $1,267,410
Contribution of Nonlinear effects into DNA structural transformations and Mechanical Properties
Granting Institution: Civilian Research and Development Foundation
Amount: $30,000
Novel tools to understand the role of ions in nucleic acid structure and function
Granting Institution: National Institutes of Health
Amount: $433, 580